Testosterone to Estradiol Ratio among Female with Polycystic Ovarian Syndrome in Khartoum State

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disease in women, characterized by heterogeneous presentation of hyperandrogenism, ovulatory dysfunc¬tion, and polycystic ovarian morphology (PCOM). This study was carried out to assess plasma levels of testosterone and estradiol among female with polycystic ovarian syndrome (PCOs). Forty clinically diagnosed polycystic ovarian syndrome (PCOs) in the period between February to May 2017, chosen randomly from Alsir Abu Hassan center for fertility in Khartoum State, and forty apparently healthy individuals as control group, to evaluate the of effect polycystic ovarian syndrome (PCOs) on plasma levels of testosterone to estradiol ratio. Plasma testosterone and estradiol measured by using ELISA, and results were analyzed using statistical package for social science (SPSS), computer programmed version 21. Anti-Müllerian hormone hormones (AMH) used for the diagnosis of PCOs and when it is levels in the patients compared to the control group. (Mean±SD: 10.6±5.92 versus 1.4±0.22) ng/ml respectively with P.Value 0.000. The study showed that, the mean plasma levels of testosterone and T/E2 ratio were significantly increase in PCOs female patients. For testosterone (1.4±1.1 versus 0.87±0.65ng/ml, p-Value =0.011). For T/E2 ratio (0.019±0.015 versus 0.01±0.008 ng/pg, p-Value =0.022). Also the finding of this study showed that, estradiol levels were insignificant difference in PCOs compared with control group. (Mean±SD: 86±39versus 101±38.6 pg/ml) respectively with P.Value 0.086. Person correlation showed that, there was insignificant negative correlation between age of PCOs female and the level of testosterone and T/E2 ratio(r= -.057- P.Value = 0.617) and (r= -.148 P.Value = 0.190) respectively and insignificant positive correlation between age of PCOs female and the level of estradiol (r= 0.193 P.Value = 0.927). There were insignificant negative correlation between the levels of testosterone and estradiol ((r= -.073 P.Value = 0.522). Also There were insignificant positive correlation between AMH and testosterone (r= 0.216 P.Value = 0.055), and insignificant negative correlation between AMH and estradiol (r= -0.010- P.Value = 0.927). It is concluded that: the plasma levels of testosterone and T/E2 ratio are higher in PCOs female patients.