Plasma Lipid ProfileAmong Sudanese Children with Malnutritionin Khartoum State

Abstract

This study was carried out to measure plasma levels of lipid profile (Total cholesterol, triglyceride, HDL-c and LDL-c) in malnourished children. Sixty samples were collected from malnourished children in period between January to April 2017, chosen randomly from Mohammed AL Amin Hamid for pediatric teaching hospital in Khartoum State, and Sixty apparently healthy individuals as control group, to assess the effect of malnutrition on plasma lipid profile levels. Estimation of plasma Total cholesterol, triglyceride, HDL-c and LDL-c levelswas done by using Spectrophotometer biosystem-310, and results were analyzed using (SPSS) computer program. The result of this study showed that, PEM most common among age between (6-9) years (85%), and malnutrition most abundant in females (56 .7%) than males (43.3%). The study results showed that, the plasma levels of lipid profile (Total cholesterol, triglyceride, HDL-c and LDL-c) were significantly decreased in Sudanese malnourished children when compare with control group. (Mean ± SD for cases versus control). For Total cholesterol (mean ± SD: 58.25 ±3.15 versus 128.33 ±5.68 mg/dl, p. value=0.000), Triglyceride (35.12± 4.63 versus 82.32 ±11.56 mg/dl, p. value=0.000), HDL-c (25.02±4.44 versus 55.12±3.70 mg/dl, p. value=0.000) and LDL-c (26.18±4.28 versus 56.85±5.39 mg/dl, p. value=0.000). Also the finding of this study showed that, there was significantly decreased in the mean of BMI in malnourished children group compared to control group. Mean ± SD for case versus control (15.28 ± 2.28 kg/m2 versus 19.25 ± 2.48 kg/m2). There were no correlation between duration of malnourished children and levels of cholesterol, HDL-c (r= 0.031, p=0.812), (r= 0.000, p=0.998) respectively, there was insignificant weak negative correlation between triglyceride and duration of disease. (r= -0.085, p=0.519) and there was insignificant weak positive correlation between LDL-c and duration of disease. (r= 0.176, p=0.817). Person correlation showed that, there were no correlation between age of malnourished children and the level of cholesterol and HDL –c (r=0.046, p=0.729), (r=0.044, p=0.740) respectively, there were insignificant weak positive correlation between triglyceride, LDL-c and age (r=0.164, p=0.212), (r= 0.167, p=0.203) respectively. It is concluded that: the plasma levels of cholesterol, triglyceride, HDL-c and LDL-c were significantly decreased in Sudanese malnourished children.