Assessment of C - Reactive Protein and High Density Lipoprotein Cholesterol in Sudanese Cigarette Smokers in khartoum State

Abstract

This is a case – control study ,conducted to determine the effect of cigarette smoking on CRP and HDL-c levels in Sudanese male cigarette smokers in period from March 2017 to April 2017 . Fifty samples were collected from cigarette smokers without disease and thirty from former smoker ( who quit smoking) without disease also and fifty non –smokers people as control were informed . Mindray (semi automated) was used for measurement of HDL-c and Quikread apparatus was used for the measurment of CRP , (SPSS)was used for the analysis of results . The study showed that there was a significant increase in CRP level and a significant decrease in HDL-c level of cigarette smokers compared to non-cigarette smokers.(mean±SD cases versus control; 6.6±1.96 versus 4.96±0.6 mg/l P . value 0.000),( 45.6±13.5 versus 66.1±3.4 mg/dl P . value 0.000) respectively. The study showed that there was significant increase in CRP level and significant decrease in HDL-c of smokers compared to former smokers (mean ±SD smokers versus former smokers : 7.4±2 versus 5.3±0.85 mg/l . P .value 0.000),( 38.3±11.4 versus 58.1±4 mg/dl . P .value 0.000 ) respectively. Pearson correlation showed that there were no correlation between CRP ,HDL-c and age ( r=0.05 p. value =0.7 ), ( r=0.15 p. value =0.27) respectively. Pearson correlation showed that there were a significant positive correlation between CRPand number of cigarette smoked per day and significant negative correlation between HDL-c and number of cigarette smoked per day (r=0.48 p. value =0.000), ( r= - 0.6 p.value 0.000) respectively . Also there were no correlation between CRP,HDL-c and duration of smoking ( r=0.08p. value =0.57), ( r=0.02 p. value =0.86) respectively. The study concluded that ,there was significant increase in CRP and significant decrease in HDL-c in cigarette smoker