Measurement of Prothrombin time, Activated Partial Thromboplastin Time, and Platelets Count Pre and Post Cardiac Surgery in Khartoum State

Abstract

The cardiac surgery activates the coagulation system with initial hypercoagulable state and platelet activation followed by factor and platelet consumption that increase risk of bleeding after cardiac surgery. This study aimed to measure platelet count, PT, INR and PTT in pre and post –surgery in patient at Sudan heart center. The study included 100 samples which were taken from cardiac surgery patients (50 pre and 50 post). Using stago –coagulometer to measure PT, INR,and APTT,Platelet count were measured used bysysmexKx21n (full automated hematological analyzer). The results showed significant increase in PT,INR and APTT level in post cardiac compare with pre cardiac,but the platelet count insignificant decreasedin post cardiac compare with pre cardiac. Also showed significant increase in PT,INR and APTT level in post cardiac compare with pre cardiac according to age groups and types of surgery and platelet count insignificantly decreased and according to gender the platelet count show significant decreased in female post cardiac compare with pre cardiac and male insignificantly decreased. This study concluded that PT,PTT,INR, showed a significant increase post –operatively when compared preoperatively,while Platelets count showed insignificant decreased post-operatively.