Measurement of Prothrombin Time, Activated Partial Thromboplastin Time and Platelets Count among Heart disease Patients in Sudan Cardiac Center Khartoum State

Abstract

Heart diseases are major health problem and greatly affecting the economic and social status of such patients. The objective of this study to measure of prothrombin time, activated partial thromboplastin time and platelets count in heart disease patients compared to control, and compared between heart disease patients them self according to age and gender to observe change which can occur. The study was carried out at the Sudan Cardiac Center, at Khartoum state, Sudan. One hundred blood samples were collected, from 70 heart disease patients and matched by 30 health persons as control. The samples were tested forprothrombin time, activated partial thromboplastin time by manual method and platelets count by sysmex21 Automated Hematology Analyzer. SPSS (version14) was used for statistical analysis. The results showed prolongationin prothrombin time and activated partial thromboplastintime in patients compared with control.The mean of PT in the patientswas 30.4±9.7 second and that of control was 13.2±1.9 second. The mean of APTT in the patients was 43.6±8 second and that of control was 32±6.5 second (P value ˂0.05). Alsono significance change occur in the mean of platelets count in heart disease patients compared to control(P value ˃0.05). Also no significance change occur in prothrombin time , activated partial thromboplastin time and platelets count between heart disease patients them self according to gender group and different age group (P value ˃0.05). Therefore its recommended that the patients must be screened always to avoid the complications of thrombosis that cause heart attack and sudden death.