Immunohistochemical Expression of Epstein - Barr virus among Sudanese Patients with Lymphoma Cancer

Abstract

This is retrospective descriptive study, aimed to study the expression of EBV among Sudanese patients with lymphoma cancer. They were conducted in Radiation and isotope center-Khartoum, during the period from September 2011 to July 2012. Fifty blocks were selected randomly from tissue block of patients with lymphoma cancer. Tissue section was stained using immunohistochemistry methods for detection of EBV marker (LMB-1). The obtained data and results were analyzed using SPSS computer program. A total of 50 samples obtained from patients with lymphoma cancer were investigated in this study (33(66%)NHL-B 3(6%)NHL-T 14(28%)HL), their ages ranged between 5 to75 years with mean age of 40 years old.28(56%) patients were males and 22(44%) were females. Twenty samples were positive expression for the demonstrated EBV marker (LMB-1); 14(28%) out of them were Non-Hodgkin's lymphoma B-cell and 6(12%) Hodgkin's lymphoma, consequently of 30 patients negative expression EBV, 19(38%) were Non-Hodgkin's lymphoma-B cell, 3(6%) Non-Hodgkin's lymphoma T-cell and 8(16%) Hodgkin's lymphoma. From the obtained results, the study concluded that, the expression of EBV marker (LMP-1) among Sudanese patients was statistically insignificant, although 20 samples positive for EBV