Design of Biosensor using COMSOL Multiphysics

Abstract

Lateral flow biosensors (LFBs) provide advantages in low cost, simplicity, rapidity, stability and portability thus making LFBs popular in biomedical, agriculture, food and environmental sciences. Currently, Computer simulation has become an essential part of biosensor design .In the past two decades, COMSOL Multiphysics Software Package have emerged as a powerful tool for simulation, particularly in Nanotechnology and most importantly in biomedical application and various application involving fluid and solid interactions. Compared with conventional component or system design, distinctive advantages of using COMSOL software for design include easy assessing to the significant parameters in various levels of design, higher throughput, process monitoring with lower cost and less time consuming. The research is Firstly focused on simulation model of biosensor based on gold nanoparticles(GNPs) designed by using Software Package (COMSOL Multiphysics), the magnitude of the laminar velocity field in the flow cell , concentration distribution in the analyte stream and surface coverage of adsorbed species and Average fractional surface coverage of adsorbed analyte were discussed from the model. Secondly the GNPs is modeled in Multiphysics then the far-field radiation pattern and the heat losses in gold nanoparticles were studied .Finally the protein adsorption is modeled in COMSOL and the concentrations of the reacting species change with the time, behavior of protein B after 5 sec and 30 sec and the velocity field were discussed and couples of suggestion are given in order to functionalize GNPs and to increase the accuracy of the biosensor design, It was obtained acceptable results