Assessment of the plasma Activity of Creatine Kinase and Creatinine Isoenzyme in Sudanese patient with Myocardial Infarction

Abstract

This study was conducted during the period to investigate the diagnostic value of cardiac creatine kinase enzyme ( CK) and isoenzymecreatine kinase (CK-MB) as myocardial markers has been assessed in this study using spectrophotometer method. A study of 30 Sudanese patient (16 male / 14 female ) admitted Sudan Center for Heart during the period April- June 2012. The patient are ofa average age “30-80” years. A group of 30 healthy subjects match in age were enrolled as control group. Blood samples were taken from all patients at first 24 hours to estimate the levels of CK enzyme and CK-MB by using spectrophotometric method. A significant increased of CK enzyme had been observed in MI patients (p<0.05), the average concentration levels (257.97±138.754) when compared to control subjects(74.97±22.785).but there was no statisticaly difference in CK-MB between patient and healthy control group(p >0.05). but clinically CKMB slight elevated in patient more than control (39.17±11.164), (10.60±5.581) respectively. the mean activities of both total CK and CKMB were not affected by sex (p > 0.05). the majority of patients admitted CCU of Sudan center of heart suffering from chest pain attack was at advanced age (40-70) years and had mean activities of total CK and CK-MB were higher than those of patients who have an age less than 40 years. In conclusion the study confirm that CK-MB is an important IV diagnostic marker that can be used for detection of myocardial infraction and follow up of patients, particularly when such information cannot be obtained following clinical and ECG examination.