Comparison between C-reactive protein and LDL-cholesterol as markers for cardiovascular diseases in Sudanese patients with Type 2 Diabetes Mellitus

Abstract

The aim of the study is to compare between C-reactive protein and LDL cholesterol as markers for cardiovascular events in Sudanese types 2 diabetes mellitus. Fifty blood samples were collected from Sudanese diabetic patients with type 2 diabetes mellitus, their age range from (35 – 80) years, and fifty healthy volunteers as control group for the comparison. Serum LDL was estimated enzymatically with spectrophotometer (Biosystem 310), and CRP was measure qualitative by slide methods. We assessed the value of these two measurements in predicting the risk of cardiovascular events in the study population. The study observed significant increase in the LDL cholesterol level in the study group of type 2 diabetes mellitus when compared with control group (130.50± 44.4 mg/dl) verses (77.76±20.96 mg/dl) respectively, (p.value = (0.00).and the level of LDL is greater in females than in males test group of type 2 diabetes mellitus (116.42±47.81 mg/dl) verses (90.71±34.1 mg/dl) respectively p.value(0.03). significant maximum elevation of LDL was observed during the early 4 period of type 2 diabetes mellitus in group 2 ( more than 10 years) (141.03±48.26 mg/dl) in contrast, the CRP reached the maximum level in group 1 (1-5 years from the onset of type 2 diabetes mellitus). These data suggest that the C-reactive protein is higher in test group of type 2 diabetes mellitus than in healthy individuals, reached the peak maximum in first five years from onset of type 2 diabetes mellitus, where LDL cholesterol level reached the peak maximum after more than 10 years from onset of type 2 diabetes mellitus.