Levels of Vitamin D and Parathyroid Hormone among Sudanese Patients with Rheumatoid Arthritis in Khartoum State

Abstract

Background:Rheumatoid arthritis is a chronic inflammatory disease in which the synovial membrane of the joint becomes inflamed, resulting in a swelling, stiffness, pain, limited range of motion, joint deformity and disability. The role of vitamin D in the pathogenesis of rheumatoid arthritis is under investigation. This study was designed to evaluate the correlation between serum values of vitamin D and rheumatoid arthritis and to correlate the relationship between vitamin D and parathyroid hormone level in this patient. Aim:To detect level of serum vitamin D in patients of Rheumatoid arthritis (RA) and to establish relationship between serum vitamin D and parathyroid hormone level in RA patient. Methods: Included 40RA patients admitted to hospital as case group, and 60 healthy individual as control group blood samples were obtained as 5ml venous blood in plain container, and then centrifuged to obtain serum which stored at -20ºC until processing. Vitamin D and parathyroid hormone levels measured by eletrochemiluminescence immunoassay technique using cobas e 411 fully automated analyzer.The data obtained were analyzed and presented using statistical package for social science (SPSS) computer software version 16 for windows. Result: The mean vitamin D serum values were 38.165±12.57nmol/L in patients and 42.63±10.56nmol/L in controls. This result showed no significant difference in vitamin D level (P.V=.066). The mean PTH serum values were 45.29±29.19nmol/L in patients and 44.10±26.17 nmol/L in controls. There was no significant difference in PTH level (P=0.835). Vitamin D level correlated withanti cycliccitrullinated peptide (ACCP) (p=0.029, R2=-0.22). Conclusion: The vit D was negatively correlated with ACCP ( R2= -0.22, P.v=0.029), the study concluded that RA have no effect on vit D and PTH level.