Assessment of the plasma activity of Aspartate and Alanine aminotransferases in Sudanese patients with liver cirrhosis

Abstract

This was descriptive analytical study done in Ibnn Sina and hospital of tropical diseases at Khartoum state in period from March 2012 to August 2012. The objective of this study was to assess the plasma activity of AST and ALT in Sudanese patients with liver cirrhosis. The subject on this study were 50 patients with liver cirrhosis (42of them were male ,8 female . The age of the patients ranged from 10- 76years, there was 50 apparently healthy individual uses as control group. All patients were suffering from lack of appetite,25 patients suffering from jaundice ,vomiting and haemoptysis , 23 of them had diarrhea or maelena ,24 were anemic and 48 of them suffering from abdominal swelling and pain. 2.0ml of blood sample from patients and control subjects were collected in lithium heparin container to estimate activity of AST and ALT by using Biosystem,s reagents and instruments. The level of AST and ALT were significantly increased in patient with liver cirrhosis as compared to control group (p=0.000) for both .and AST /ALT ratio was significantly increase as compare to control group (p=0.006) AST level were not affected by presence of ascites (p-value 0.725).or portal hypertension (0.71),while ALT level was significantly affected by presence of portal hypertension (p-value 0.001) and not affected by presence of ascites (p=0.06) There was insignificant difference in level of AST,ALT and AST/ALT ratio in different cause of liver cirrhosis (p=0.657) ,(p=0.66) ,(p=0.646) respectively. Duration was insignificantly affected the level of AST(p=0.57).ALT (p=0.441) and AST/ALT ratio(p=0.911).