Estimation of Prothrombin Time, Activated Partial Thromboplastin Time and Fibrinogen level in Patients with Liver Disease in Khartoum Teaching Hospital

Abstract

This is a hospital based, analytical, descriptive, cross sectional and case control study was conducted in Khartoum teaching hospital during period from 5 March 2012 to 22 June 2012, aimed to determine prothrombin time (PT), international normalization ratio (INR), activated partial thromboplastin time (APTT) and fibrinogen level among liver disease patients. Blood samples were collected from sixty patients with liver diseases(chronic liver disease, hepatitis B and C viruses, cirrhosis, jaundice and hepatocellular carcinoma) as case group and thirty samples were collected from healthy individuals as control group into citrate containers. Citrate blood samples were centrifuged to harvest platelets poor plasma for measurements of PT, INR, APTT and fibrinogen level using sysmex CA500 coagulometer. Data obtained were analyzed using Statistical Package of Social Sciences (SPSS version 11.5). The result revealed that there was significant increase in PT, p. value (0.00), INR p. value (0.00) , APTT p. value (0.00) and significant decrease in fibrinogen level p. value (0.00) among patients of liver diseases when compared with control group. There were no any changes in PT, INR, APTT and fibrinogen level related to age and gender. The study concluded that PT ,INR and APTT in patients with liver diseases were increased and Fibrinogen level was decreased in liver diseases compared to normal control.