Preparation of some mefenamic acid derivatives

Abstract

Nine new substituted mefenamic acid derivatives were synthesized by the reaction between the amino group in mefenamic acid and acyl chloride to give tertiary amine and reaction of free carboxylic acid of mefenamic acid with alcohol to give ester, ACD/Lab program method for Moleculardesign was described. The results on application of ACD/Lab program in calculation and correlation of structure properties of the some mefenamic acid derivatives reported. The synthetic design of these compounds was achieved through retrosynthetic analysis (RSA) approach. The reaction progress for all synthesized compounds was checked by (TLC) and m.p. techniques, and the structures of the synthesized compounds were confirmed using IR, 1HNMR, UV, and GC-MS.