Assessment of Serum Levels of Creatinine and Urate among Sudanese with Type2 Diabetes Mellitus

Abstract

This is a cross- sectional study conducted during the period from March 2012 to October 2012. The aim of this study to assess the serum levels of creatinine and urate among Sudanese with type2 diabetes mellitus. Sixty patients with type2 diabetes mellitus were selected as a test group from the military hospital in Khartoum state, Sudan. The test group was compared with a control group which included 40 healthy volunteers. Age and gender of the test group were matched with the control group. Blood specimens were collected from both groups and the serum levels of creatinine and urate were estimated . Cobas integra 400plus from Roche campany was used for measurement of serum levels of creatinine and urate . Statistical package for social science (SPSS version 11.5) computer software was used for data analysis. The results of this study indicates a significant increase in the means of the serum levels of creatinine and urate in type 2 diabetic patients (test group) compared with non diabetic subjects as control ( P ≤ 0.05 ). The results of the current study indicates a significant, strong positive correlation between the duration of the diabetes mellitus type 2 with both serum levels of creatinine and urate. Also significant a weak positive relationship was observed between the serum levels of creatinine and the BMI and Insignificant a weak positive relationship was observed between the serum levels of urate and the BMI. Inconclusion; the serum levels of creatinine and urate are increased in diabetic patients with type 2 diabetes mellitus.There is strong positive correlation between creatinine and urate and the duration of diabetes mellitus. There is a weak relationship between the serum levels of creatinine and the BMI , and no correlation between the serum levels of urate and the BMI .