Immune Response to Hepatitis B Vaccination among Medical Laboratory students in Omdurman Islamic University

Abstract

Hepatitis B Virus infection is a major public health problem and causes majority of primary liver cancer. This was descriptive and cross sectional study aimed to evaluate the immune response after hepatitis B Vaccination in Medical laboratory Students. Study was conducted among Medical laboratory students in Omdurman state (Omdurman Islamic University) from April (2015) to May (2016). The blood specimens were collected and sera were separated and stored at -20ºC until used, sera were tested using ELISA for qualititative detection of anti HBVs Ag. Of the total 90 students, with mean age of 25 years included 70 vaccinated students, 62/70 (88.5 %) were responded to HBV vaccine and 8/70 (11.4%) were non responded, of the 20 unvaccinated students only 1/20 (5%) was reactive. Out of seventy vaccinated students 35 were females and 35 were males, females immunologic response were significantly higher than males ( p.value :0.000). Responsiveness was significantly lower in smokers than non-smokers. Diabetes was a risk factor it was found to be significantly correlated ( p.value:0.00) with hepatitis B vaccination irresponsiveness.