Synthesis of some Mannich base derivatives

Abstract

Some of β-amino keto compounds were synthesized by Mannich base reaction in order to apply this reaction on different amines, ketones with benzaldehyde. These reactions were performed by three component condensation and resulted in the expected compounds. A number of Mannich bases compounds were selected to be synthesized according to some factors which affected the reactivity and stability of these compounds, and the design and properties of Mannich bases were done by using computational program (ACD/Lab). Experimental work based on changing the solvent and conditions was also attempted. Elucidation of the structure of the synthesized compounds was performed using spectroscopic techniques (IR and H1NMR) and thin layer chromatography (TLC). These spectra and chromatograms confirm the expected structure of the synthesized products. The percentage yields and melting points of all synthesized compounds were obtained.