Assessment of High Sensitive C reactive Protien of Hepatitis B in Sudanese Patients in Khartoum State

Abstract

CRP was the first acute phase protein to be described and is sensitive systemic marker of inflammation and tissue damage especially in liver disease . hepatitis B viruses Is a common health problem throughout the world and one of the major risk factors for liver disease. General objective: To assess High Sensitive C-reactive protien of Hepatitis B in sudanese Patients In Khartoum State. Specific Objective: To assess CRP levels an study Group To correlate between CRP level and duration of disease ( acute and chronic Group ) Material and Methods This is case control study conducted in Saba clinic in Khartoum state during march to June 2015 . Sixty hepatitis B positive patients as test group with fifty healthy subject s control group were enrolled in this study .Plasma CRP level was estimated using Nycocard CRP Single test .Data analyzed using SPSS computer program. Result The result of showed the mean plasma level of CRP was significantly increased in case group (p.value 0.001) compare with control group The mean plasma level of CRP was significantly increased in hepatitis B virus case group ) classified based on duration of disease (p.value 0.001). Pearson correlation showed , there was weak correlation between CRP level and duration of Hb Ag virus disease, (r 0.554 , p.value: 0.113),and negative correlation between CRP level and acute duration of Hb virus disease, (r : -0.015, p.value:0.937) Conclusion In conclusion CRP is useful for of hepatitis B patients, since they tend to have higher CRP level compared with control group. The Study conducted there is a significant increase in mean of CRP level in chronic hepatitis B patients compared with acute.