Determination of Lipids Profile of Sudanese Chronic Renal Failure Patients - Khartoum State

Abstract

This study was conducted to measure serum levels of plasma lipids (TG, TC, HDL-c and LDL-c) in patients with chronic renal failure. Seventy fife random samples were collected from patients were alredy attended ALnaw Teaching Hospital during the period between January to march 2015 chosen randomly and seventy fife apparently healthy individuals were selected as controls. Enzymatic method was used to estimate serum lipid profile levels manually using Biosystem kits and by using Mindary, and results were analyzed using (SPSS) computer program (T- test and ANova test). The results showed that serum levels of TG,TC, and LDL were significantly increased (p-value = .000) (p-value = .001) (p-value = .000) respectively and the serum levels of HDL were significantly decreased (p-value = .000) in the Sudanese patients group. TG serum level increasd between (101.5±35.8) in control to (132.2±56.3) in patients, TC also increased to (138.0±42.0) compared to control (121.6±23.0). LDL showed the same pattern and significantly increased to (133.8±43.1) in compare to control (92.8±37.8). HDL of patients decreased to (31.8±4.0) while in control was (37.0±5.4). According to causes of renal failure the results of this study showed that; hypertension, diabetes and family history are the most common causes in Sudan. The results of this study showed that there is a weak correlation between TG levels and duration of hemodialysis at (r = .223, p-value=.054). No correlation between TC (r=.166, p-value =.154), HDL-c (r=.166, p-value =.156) and LDL-c (r=.133, p-value =.254) levels and duration of dialysis was observed. In conclution: the serum levels of TG,TC, and LDL significantly increased in Sudanese all patients, but serum levels of HDL significantly decreased in all patients subjected them to risk of many complications.