Assessment ofGamma GlutamylTransferase and LactateDehydrogenase as Biochemical Markers of Severityof Preeclampsia in Sudanese Pregnant Women’s in Khartoum State

Abstract

Background: Preeclampsia is a pregnancy-specific disease with multisystem complications. Several potential markers have been proposedto predict the severity of preeclampsia, preeclampsia constantly associates with high blood pressure. There are very limited studies with conflicting data on GGT and LDH in preeclampsia. This study was undertaken to investigate the possible role of GGT and LDH in the prediction of severity of preeclampsia to prevent further complications. Objective: To assessofGammaGlutamylTransferase and Lactate Dehydrogenase as Biochemical Markers of Severity of Preeclampsia in Sudanese pregnant women in Khartoum stateand comparison with healthy normotensive pregnant controls. Material and method: This is a case control hospitalize base study.The study was conductedin preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In thisstudy glutamyltransferase and lactate de-hydrogenase was estimation in 100Sudanese pregnant womenby spectrophotometermethod, 50of them were diagnose with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Classify severe and mild preeclampsia according to blood pressure; Mild preeclampsia wasdefined as onset ofhypertension after 20 weeks of gestation with diastolic blood pressure (DBP) >90 and ≤ 110 mmHg with or without proteinuria. When diastolic blood pressure (DBP)>110 mmHgwith significant proteinuria Preeclampsia was considered as severe. And 50 are normal pregnancy women in third trimester in Omdurman city hospitalsduring March to June 2015.The data was recorded and analyzed using statistical package for social sciences (SPSS –version 16) on programmed computer. Result: The mean values of plasmagamma glutamyltransferase in mild preeclamptic pregnant women were insignificant difference when compared to control Pvalue=0.346. The mean values of plasma gamma glutamyltransferase in mild preeclamptic pregnant women were insignificant difference when compared to control P value=0.089. Themean values of plasma lactate dehydrogenase in mild preeclamptic pregnant women were significant increase when compared to control Pvalue =0.008. Themean values of plasma lactate dehydrogenase in severe preeclamptic pregnant women were significant increase when compared to control P value =0.001. Result showedsignificant positive moderate correlation between lactate dehydrogenase and diastolic blood pressure in sever preeclampsia p value = 0.006 and Pearson correlation r = .851.andsignificantpositive moderate correlation between lactate dehydrogenase and diastolic blood pressure in mild preeclampsia p value = 0.013 and Pearson correlationr = .782.and insignificantcorrelation between gamma glutamyltransferase and diastolic blood pressure in sever preeclampsia p value = 0.359 andPearson correlation r = .215.andinsignificantcorrelation between gamma glutamyltransferase and diastolic blood pressure in mild preeclampsia p value = 0.652 and Pearson correlation r = - .189. Conclusion:from the result of this study it is concluded that: levels of LDH is raised in Sudanese pregnant women with hypertensive preeclampsia. Andlevel of GGT level normal in Sudanese pregnant women with hypertensive preeclampsia. And showed significant positive moderate correlation between lactate dehydrogenase and diastolic blood pressure in Sudanese pregnant women with hypertensive preeclampsia disease. And showed insignificant correlation between gamma glutamyltransferase and diastolic blood pressure in Sudanese pregnant women with hypertensive preeclampsia disease.