Sero-detection of Epstein Barr Virus IgGAntibodies among Leukemic Patients in Khartoum State

Abstract

The main aim of this study was to determine the sero prevalence of Epstein-Barr virus (EBV) IgG antibody using enzyme linked immunosorbent assay (ELISA) among leukemic patient attending Radiation Isotop-center-Khartoum (RICK )from April to June 2015 This study had also examined age, gender and type of leukemia antibodies as risk factors. A total of 80 subjectsof leukemicpatients were examined. The results revealed that the prevalence of Epstein-Barr virus (EBV)IgG among total leukemic patients was 60(75%) The results showedthat the prevalence of Epstein-Barr virus infectionwas21 (23%) in patient withacute lymphoid leukemia(ALL), 13 (14%)inchronic Leukemia(CLL), 8(8.9%) acute myeloid leukemia (AML) and 18(20%. chronic myeloid leukemia (CML) .According to gender it was 34(42.5%) in males,in females 26(32.5%). Also the results showed high occurance of EBV IgG antibodies in age groupsbetween (1-20)years which represent21(26.3%), followed by the age groups between(41-60) years which represent 19(23.8%) and then age groups between (21-40)years represent 16 (20.0%),and less occurance in age groups between (61-80)which resemble 4(4%). From this Study concluded that there is significant correlation between leukemia and Epstein-Barr virus .The study showed that EBV was one of the causes of leukemia and recommended further studies to enhance these results.