Immunohistochemical Expression of CEA Tumor Marker in Colorectal Carcinomas and its Association with CK20

Abstract

This study carried out in Khartoum state during the period February 2012- September 2012. The study aimed to detect the expression of carcino embryonic antigen (CEA) tumor marker in colorectal carcinomas and its association with cytokeratiens 20 (CK20) using immunohistochemistery technique. Fifty formalin-fixed paraffin embedded tissues that were previously diagnosed as colon cancer with different histological types classified as non mucin secreting which the highest one that constituted 43(86%), followed by mucin secreting carcinoma 4(8%) ,2(4%) tubular carcinoma and1(2%) lymphoma, most cases were classified according to tumor grades as moderately differentiated tumor. The age of study group range between( 30- 80) years and majority of cases within age grouping 41-50 years and 51-60years constituted 16(32%) cases for each. Males were affected more than females constituting 28(56%) and 22(44%) respectively. Forty one (82%) of cases were positive for CEA tumor marker. Out of 47(94%) positive for CK20, 40(80%) were positive for CEA, while other 3(6%) cases that negative for CK20, 1(2%) was positive for CEA. According to this findings the study conclude that CEA has high expression among colorectal carcinomas grades with significant correlation between CK20 and CEA expression .