Assessment of liver enzymes level among Sudanese gasoline station workers

Abstract

Gasoline use is widely spread throughout the world. The effects of gasoline inhalation on human health are serious and in many cases, deadly.This is a case control study conducted during period from February to March2015 to measure AST, ALT and ALP activities between gasoline station workers and non gasoline station workers. Fifty gasoline station workers were selected as test group and 50 non gasoline station workers as control group (age was matched (17-55)). Blood specimens collected from both groups, and serum AST, ALT and ALP activities were determined by using autoanalyzer (centronic). A significant increase in means of serum AST, ALT and ALP activity in smoker when compared to control group, P. value = (0.001), (0.01), (0.001) respectively .The results also showed a significant positive correlation between age and serum AST, ALT and ALP activity (Serum AST activity P= 0.0001, r = 0.67), (Serum ALT activity P=0.0001, r = 0. 45) and ALP (P= 0.02, r =0.23).Statistical analysis also showed a significant positive correlation between duration of smoking and serum AST, ALT and ALP activity (serum AST activity P=0.04, r =0.28), (serum ALT activity P=0.045, r =0. 28),and (serum ALP activity P=0.001, r =0. 44) . The study results revealed that gasoline inhalation leads to significant elevation of serum AST, ALT and ALP. Increases in AST,ALT and ALP is proportional with duration of work at gasoline station per years ,also The serum AST and ALT activities are showed significant positive correlation with age . Serum AST, ALT and ALP activities are showed significant positive correlation with duration of work at gasoline station workers