Synthesis of some β- amino acetophenone derivatives

Abstract

The introductory chapter of this thesis outlines multicomponent reactions and describes in detail the chemistry of the Mannich reaction. The final section of the introduction deals with chemical informatics Ten compounds of β-aminoacetophenone derivatives were synthesized by the condensation of ketone (acetophenone or p-bromoacetophenone) with different aromatic amines and benzaldehyde; general preparative method, ACD/lab programmer method and Swiss target prediction method for synthesized compounds were also described. The results and discussion focused on application of ACD/Lab programmer in calculation and correlation of structure properties of the some β-amino acetophenone derivatives, elucidation of the structures of the synthesis compounds by various spectroscopic methods (IR and 1 HNMR) calculations of the percentage, Rf value and the melting point of the synthesized compounds.