Measurements of Platelets Activity in End Stage Renal Disease Patients in Al-Ribat Hospital – Sudan From March to May 2014

Abstract

End stage renal disease (ESRD) is a major health problem in Sudan which is stage five of chronic renal failure leading to many complications. Patients need to dialysis as a treatment to survive. Haemodialysis leading to platelets abnormalities (chronic platelets activation) while the platelets play a major role in haemostasis and they are natural source of growth factors which are play a significant role in repair and regeneration of connective tissues in healthy individuals. This analytical descriptive cross sectional case-control study was conducted in Al-Ribat Hospital during the period from March to May 2014.The aim of the study was to determine the changes in platelets activity by measuring platelets count and platelets indices (MPV,PDW, and P-LCR) among Sudanese End Stage Renal Disease Patients attending Al-Ribat Hospital in the renal dialysis unit. Eighty four blood samples were collected from the patients with end stage renal disease (ESRD) and fifty blood samples were collected from apparently healthy (controls) individuals. 2.5 ml of blood was collected from each patient and control , automated haematological analyzer ( Sysmex KX-21N) was used to measure platelets count, MPV, PDW, P-LCR. Informative data of age and gender , were collected using a questionnaire during the period of March to May 2014. Firstly, the Age in this study was divided to three groups (20-40), (40-60), (60-80) years. The study results revealed that platelets count was significant decreased and MPV was significant elevated on the end stage renal disease patients. The mean value of patients with end stage renal disease of platelets count (185.25± SD) and mean value of MPV (13.02± SD) respectively .The mean value of Platelets count (274.86± SD) and mean value of MPV (9.36± SD) in control group respectively. The study concluded that there was a significant effectiveness of platelets count and MPV on ESRD patients , the other parameters (PDW and P-LCR) have no significant effectiveness on ESRD patients. Also, no significant effectiveness of gender on platelets count, MPV, PDW, and P-LCR of end stage renal disease patients, and there was no significant effectiveness of age on PDW and P-LCR of end stage renal disease patients but there was an age effectiveness on platelets count ( inverse relation) and also there was an age effectiveness on MPV (direct relation) of end stage renal disease patients