Assessment of cholinesterase activity as liver function marker among Sudanese Cirrhotic Patients

Abstract

Background: It is suggested that cholinesterase level effected by liver cirrhosis due to hepatocyte hurts. The objective of this study was to determine the cholinesterase values with association of albumin and prothrombin among both stages cirrhotic patients. Methods: A case control study was conducted on 50 cirrhotic patients(case group) and 50 apparently healthy people (control group), attended to numbers of the Sudanese hospitalsfor regular follow-up and blood samples were collected according to study criteria. Cholinesterase activity and albumin level weremeasured using spectrophotometric methods, PT was measured by using Coagulometer. Results: using analysis of variance cholinesterase level were analyzed, using correlation the correction between cholinesterase and albumin and PT was analyzed. cirrhotic patients grouped into two groups (A, B)depend on disease severity and stages. Cholinesterase level was significantly decrease in group A (3143.83±1583.44) and group B(1895.32±531.79)p.value 0.000. In cirrhotic patients cholinesterase level was positively correlated with albumin level and negatively correlated with PT. in group A cirrhotic patients cholinesterase was positive correlated with albumin and there is no correlation with PT, in group Bthere is no correlation between cholinesterase, albumin and PT. Conclusions: The study concluded that, cholinesterase level revealed liver cell conditions if it have low level that’s means there are damage in liver cells and this is more useful in assessment of synthetic power of the liver .