The Effect of Hemodialysis on Alanine Transaminase And Aspartate transaminase(ALT&AST) levels in Patients with Renal Failure

Abstract

This study was carried out to measure serum levels of the liver enzymes; aspartate transaminase and alanine transaminase in patients with renal failure under hemodialysis. Eighty samples were collected from patients in period between January to March 2015, chosen randomly from ALnaw teaching hospital and Alrebat teaching hospitals, and forty apparently, healthy individuals as controls, to assess the effect of hemodialysis on liver transaminases enzymes level. Measure serum aspartate transaminase and alanine transaminase were measured by using autoanalyzer mindray BS 200, and results were analyzed using statistical of package social science (SPSS), computer program. The study showed that the serum levels of aspartate transaminase" AST", and alanine transaminase "ALT" were significantly decreased, (p-value =0.00) in the patients under hemodialysis group. Mean±SD controls versus cases. (34±7versus15±5u/l) for AST, (24±7 versus 10±4 u/l) for ALT. Also the serum levels of liver transaminase enzymes were measured in 20 cases with renal failure under hemodialysis, to compare the levels of them before dialysis and post dialysis, showed (AST&ALT) were significantly decreased (p-value=0.00) in cases before dialysis when compared to the levels of them after dialysis. Mean ± SD for predialysis versus post dialysis. (13±4 versus 22±4u/l) for AST, (8± 4 versus 17± 3 u/l) for ALT. The study indicates that there was no significant difference between the levels of liver transaminase enzymes according to gender "males or females". The results as follow;