Measurement of Serum Ferritin Level among Acute Myeloblastic Leukemia Patients ـKhartoum State

Abstract

This study aimed to estimate and assess the level of serum ferritin among AML patients in Khartoum State. General objective of this work was to study serum ferritin level among acute myeloblastic leukemia patients in Khartoum State. It is a descriptive study, conducted in National Center of Radiotherapy and Nuclear Medicine in Khartoum, Sudan, during the period from Oct 2014 until Nov 2014. Data was collected by pre-coded questionnaire and analyzed by standard program of SPSS version 17, 2008 statistical package. Study included 40 AML diagnosed patients with age between 16-67 years old, they were 21 males (52.5 %) and 19 females (47.5%). Ferritin concentration was measured in serum by using Biosystem Clinical Analyzer A15 (Barcelona, Spain) with a commercial ferritin latex kit. Serum ferritin level among AML patients was significant higher than the normal reference value (P=0.00), mean serum ferritin level in AML patients was (431.86±16.61µg/L). Serum ferritin level correlated positively with TWBCs (r=0.345) (P=0.029) and no correlation with Hb concentration (P=0.604) was found. There was no significant difference of serum ferritin level between FAB subclasses of AML (P=0.107). There was no variation among age (P=0.900) and no significant difference between males and females patients with AML (P=0.154) in regard to serum ferritin level. No correlation found between serum ferritin level and blast% (P=0.703). Study concluded that serum ferritin level can contributed in initial evaluation of AML disease.