Seroprevalence of Enteric Fever among Blood Bank in Khartoum State - Sudan

Abstract

Typhoid fever is a systemic illness with a significant morbidity and mortality in developing countries. Poor sanitation, overcrowding, low standard of living, lack of medical facilities, and indiscriminate use of antibiotics lead to endemicity of typhoid fever and multi-resistant strains of Salmonella typhi in developing countries. The aim of this study is to determine seroprevalence of Typhoid fever among Blood Donors attending Central Blood Bank in Khartoum State in Sudan. The total of one hundred samples was collected from healthy blood donors in the period from September to December, 2014. The diagnosis of typhoid fever in this study was based on Standard Agglutenation Test (SAT) to determine the titer of Salmonella typhi OAg and Salmonella paratyphi B Ag and typhidot Immunochromatographi test (ICT) to screen the presence of anti Salmonella antibodies. Males were 81(81%) and females were19 (19%). The reactive sera of total samples were 33 (33%), and non-reactive sera were 67 (67%). The agglutination results of typhoid fever among blood donors for salmonella typhi O Ag were (significant, doutfull, insignificant and negative) as (19(19%), 11(11%), 3(3%), 67(67%)) respectively. The agglutination results of typhoid fever among blood donors for Salmonella paratyphi B Ag were (significant, doutfull, insignificant and negative) as (11(11%), 12(12%), 4(4%) 73(73%) respectively.The result of typhidot test were :positive sera were 46(46%) and negative sera were 54(54%) and all the positive sera were IgM antibody