Evaluation of Serum Uric acid Levels among Vitamin D Deficient Hypertensive Patients in Khartoum State

Abstract

Hypertension is a common health problem throughout the world. Some evidence suggests that Vitamin D may reduce hypertension prevalence through its action on Renin-Angiotensin System (RAS), intracellular calcium homeostasis, and regulation of vascular smooth muscle contractility This is a descriptive cross-sectional study carried out to evaluate serum uric acid levels among hypertensive vitamin D deficient patients, and to correlate serum vitamin D and uric acid to the study variables (age, body mass index, gender and duration). Eighty eight hypertensive patients were enrolled in this study was done in Khartoum state during the period of March to July 2014, Serum vitamin D level for patients was estimated using ELISA competitive assay, serum uric acid level was estimated by spectrophotometer method, data analyzed using T-test and Pearson correlation in SPSS computer program. The results showed equal percentage of hypertension among females (52.3%) than of the males (47.7%), overweight group (80.4% males, 66.7% females) were more frequent than normal weight group (19.6% males, 33.3% females), vitamin D deficient females (81.0%) were more than males (45.0%), vitamin D deficiency in the males (74.7% in the normal weight group, 50.0% in the overweight group), in females (64.3% in the normal weight group, 89.3% in the overweight group), females and overweight group expose to vitamin D deficiency more than males and normal weight group, (P value 0.000, 0.033) respectively, vitamin D level decreased (P value 0.041) with duration of hypertension. The correlation analysis between vitamin D and uric acid resulting in week positive correlation (Pearson's r: 0.019 P value =0.033). In conclusion hypertension is associated with vitamin D deficiency which affected by gender and weight, further studies is needed to determine the effect of uric acid on the hypertension and study variables.