Determination of Complete Blood Count among Sudanese Patients with Hyperthyroidism and Hypothyroidism in Khartoum State

Abstract

This is across sectional study carried out in Khartoum state in Military Hospital during the period from February 2014 to April 2014 . One hundred patients were selected 82 with hyperthyroidism and 18 with hypothyroidism , in addition to 30 euthyroid persons were selected as a control group. The study group selected with age range from 20 and 70 years. 3 ml of venous blood was withdrawn from each participant , placed in a test tube containing EDTA which act as anticoagulant. Complete blood count were determined using an automated cell counter (sysmex KX-N21). The results were analyzed by Statistical Package of Social Science program. The results showed that the percent of female with hyperthyroidism and hypothyroidism higher than percent of male .Increase number of male aged between 61 and 70 years. And increase number of female aged between 20 and 30 years. Significant decrease in red blood cell, mean corpuscular volume and haematocrit in patients with hypothyroidism compared to control group ( P value < 0.05). haematocrit , mean corpuscular volume and mean corpuscular haemoglobin showed significant decrease in hyperthyroidism group when compared to control group. no significant differences were noted for total and differential leukocyte counts between euthyroid , hyperthyroidism and hypothyroidism group ( P value = 0.05). Platelet showed significant decrease in hyperthyroidism group and insignificantly decrease in hypothyroidism group. . These results showed that the mean counts of red blood cell , Haematocrit and mean corpuscular decrease significantly , white blood cell increase insignificantly and platelet decrease insignificantly in hypothyroidism group. haematocrit, mean corpuscular volume, mean corpuscular haemoglobin and platelet significantly decrease , while white blood cell and differential leukocyte counts were insignificantly decrease in hyperthyroidism group. According to the obtained data it is suggested that all patients with hypothyroidism and hyperthyroidism should be periodically checked for any possible hematological changes.