Assessment of Serum Total Cholesterol Level of Sudanese patients with Thyroid Dysfunction in Khartoum State

Abstract

This study was carried out during the period of (February – July 2014) in order to assess the level of total serum cholesterol in 100 patients with hyperthyroidism and hypothyroidism. Three groups were involved in this study. 50 patients with hypothyroidism and 50 with hyperthyroidism and 30 subjects apparently healthy as control group. All the participants attended at Khartoum Teaching Hospital. Five ml of venous blood was collected from patients, Serum was used to measure T3, T4, TSH and total cholesterol then the data was analyzed by using the computer program SPSS version 11.5 to obtain Mean ± SD, Independent T test and correlations. Level of significance was ≤ 0.05. The automated Immunoassay method was used for estimation of thyroid function tests (TFT). The enzymatic colorimetric (Oxidase/Peroxidase) method was used for estimation of total cholesterol levels. The study findings showed that majority of patients were females and the patients representing the age between 30 -45 years. The results showed that the level of total cholesterol was significantly decreased in patients with hyperthyroidism compared to control subjects. (128 mg/dl ± 30 mg/dl) versus (175 mg/d l± 27 mg/dl) respectively, (P value < 0.05). The level of total cholesterol was significantly increased in patients with hypothyroidism compared to control subjects (198 mg/dl ± 43 mg/dl) versus (175 mg/dl ± 27mg/dl) respectively, (P value < 0.05). There was a significant positive correlation between the level of serum total cholesterol and levels of TSH (r=0.48, P value= 0.000), the results also showed there a significant negative correlation between levels of serum total cholesterol and levels thyroid hormones (T3 and T4), (r=-0.57, P value =0.000) and(r= -0.59, P value= 0.000). The results concluded that hyperthyroidism and hypothyroidisms have an effect on total cholesterol levels resulting dyslipidemia.