Estimation of Fibrinogen level in Pregnant Women at 3rd Trimester in Different Ages in Khartoum State

Abstract

In Pregnancy many clotting factors increase and anticoagulation factors decrease causing augmented coagulation and decrease fibrinolysis . Haemostasis abnormalities have been associated with various complications of pregnancy. Pregnancy is a hypercoagulable state with changes in procoagulant, anticoagulant, and fibrinolytic systems. This study was aimed to look at the changes in plasma fibrinogen level among different age groups in pregnant Sudanese ladies at third trimester. This study was carried out at Khartoum Teaching Hospital and Medical Corps Hospital from March to June 2014.This study included 100 ladies at third trimester of pregnancy and 20 non-pregnant ladies as control group at different ages between 15 and 45 years. All ladies gave their consent before entering the study blood samples were taken from both groups for measurement of fibrinogen. The one sample T-test and correlation coefficient study were used for statistical tests. The Results show There was significant difference in mean plasma fibrinogen between pregnant ladies at 3rd trimester (4.245±0.72) and control group (2.330±0.45). (P value <0.0001) , and no correlation between fibrinogen level in pregnant ladies at 3rd trimester and age group and insignificant p.value (0.911) There is a significant increase in plasma fibrinogen level in pregnant ladies at 3rd trimester in compare to control group and there is no significantly difference in fibrinogen level between different age group in pregnant ladies at 3rd trimester.