Evaluation of some Haemostatic Parameter Among hyperthyroidism and hypothyroidismPatients in Khartoum State.

Abstract

This is an analytical case control study ,it's aim to determine the changes induced by hyperthyroidism and hypothyroidism in platelet count , PT(INR) and APTT .It was conducted at the Radiation Isotope Center Khartoum State during the period March to June 2014.The study population was 30 patients with hyperthyroidism , 30 patients with hypothyroidism and 30 normal individuals ( control group) . A questionnaire was used to obtain patients’ information as age, gender, duration of diseases, treatment ,use of salt and family history.The participants were orally interviewed after an informed verbal consent was taken . In both cases of hyperthyroidism and hypothyroidism the majority were females ,aged 31-45,more than 50% have family history of the disease, with a disease duration of less than one year in 90%of the cases and the majority did not use iodized salt . Five ml of venous blood was collected from all the participants. Sysmex CA-50 automated blood coagulation analyze was used for measuring activated partial thromboplastin time(APTT) and prothrombin time(PT)and platelet(PLT) count was performed by Sysmex KX-21 hematological autoanalyzer. APTT value was significantly lower (P≤0.05) in patients with hyperthyroidism (26.61±2.86) than in the control group(33.2±2.86). Hypothyroidism patient showed APTT values(33.84±3.28 ) similar to that of the control group and it was significantly (P≤0.05)higher than that of hyperthyroid cases. PT values in both patients with hypothyroidism (10.20±1.67) and hyperthyroidism (11.2±1.95)were significantly lower (P≤0.05)than that of the control group (13.6±1.23) Hypothyroid patients showed a significantly (P≤0.05) higher reduction in PT value than hyperthyroid patients. No significant variation was observed in the PLT count among the study population. It was concluded that both hypothyroidism and hyperthyroidism are associated with significant abnormalities in some of the coagulation parameters.