Abstract:
This retrospective study was conducted at Soba University Hospital and Sudan
University of Science and Technology during the period from April to
September 2007, The study aimed to detect the presence of Prostatic Specific
Antigen PSA, and to identify collagen fibers in tissue affected with prostate
cancer and benign prostatic hyperplasia.
49 samples were selected and classified into four categories that were
previously diagnosed as: ten samples were diagnosed as benign prostatic
hyperplasia, three samples were diagnosed as well differentiated
adenocarcinoma, eighteen samples were diagnosed as moderately
differentiated adenocarcinoma, and eighteen samples were diagnosed as
poorly differentiated adenocarcinoma, PSA was identified using
immunohistochemical method, by using dako system (Invision) technique.
This study concluded that there was association between PSA and prostatic
cancer.
Also Collagen fiber was identified using Masson Trichrome stain, The
morphology of collagen fibers, show different characteristic feature according
to the pathological process, accordingly it was sparse in amount in case of
benign prostatic hyperplasia and was more dense in case of malignant cases
more over the amount of fibers is increasing with grading of the tumors.
