Abstract:
Thalassaemias are group of genetic disorders of haemoglobin synthesis,
resulting from reduced rate of production of one or more of globin
chains. It is prevalent in many countries and about 3% of the world
population carries the gene. The study was conducted on 263 individuals
belong to 10 different families in Jenin area in Palestine in the period
Jan.2007 to Dec.2008.
Adescriptive cros-sectional study was conducted to find out the
distribution of beta Thalassaemia and other Hb variants in that families.
Blood samples were subjected for Complete Blood Count (CBC), gel
electrophoresis and ion exchange chromatography. The results were filed
and subjected to SPSS for analysis.
The study showed that beta Thalassaemia present in high percentages
(elevated Hb-A2 and Hb-F) in Torokman (25%) and Aboalrob (23%) with
overall percent of (15%). The study detecs sickle cell Hb (HbS) in
Qalalweh(41%), Noairat(27%) and Aboalrob(14%) and does not present
in Ziud, Daraghmeh, Jaradat and Torokman.
The Hb concentration and other blood indices vary significantly among
families. Also shows no correlation between color of eye, color of hair,
type of hair and length of individuals and the concentration of Hb
variants. The study also correlate between electrophoresis and
chromatography with respect to Hb-A2 measurement.
The study recommended that individuals belong to Torokman, Aboalrob,
Qalalweh and Noairat should be subjected to haematological screen and
advice to avoid carrier partners. Those individuals with reduced Hb,
PCV, MCV and MCHC should be subjected to electrophoresis. The study
also recommended giving the persons in the community information's
about Thalassaemia and sickle cell anaemia.
Further studies are recommended in other families in the area and
Palestine.
