Abstract:
This was analytical, descriptive and cross-sectional study conducted to determine
the frequency of the sickle cell disease and sickle cell trait in Sudanese patients referred to
Heglig hospital in West region of Southern Kordofan state in the period between
November 2008 to February 2009.
One hundred (100) patients were informed about the study and informed consent
for participation was obtained. A venous blood of 2.5 ml was collected in ethylene-
diamine-tetra-acetic acid ( EDTA) containers and investigated for sickle cell disease and
sickle cell trait, a complete blood count (CBC)[ semi automated hematological analyzer
(Sysmex Kx 21N) was used], sickling test and hemoglobin electrophoresis
(Electrophoresis tank and power pack was used )were carried out .And statistical package
for social sciences (SPSS) computer program version 13 was used for data processing.
The mean age of the sickle cell disease patients was (10.32/year). The results
showed that percentage of sickle cell trait and sickle cell disease were (45%) and (18%)
respectively.
Hemoglobin level, total erythrocyte and packed cell volume of the sickle cell
disease patients were (7.03g/dl), (2.68х106/ μl) and (22.52%), respectively.
There were no significant differences in sickle cell disease and normal individuals
in mean cell hemoglobin concentration (31.2%), mean cell volume (86.85fl) and mean
cell hemoglobin (27.16p.g) (p < 0.248, p < 0.399 and p < 0.769 respectively,
The total leukocytes (15.53х103/ μl) p < 0.000) and platelets count (393.05 х 103/
μl) p < 0.003) were significantly elevated in sickle cell disease when compared with
normal individuals.
In conclusion, sickle cell anemia is highly frequent in the studied area, which is
most likely due to the consanguineous marriages.
