Abstract:
This is a descriptive retrospective study conducted in Khartoum state hospitals
(RICK, Military and Alribat National) during the period from December 2009 to
April 2010.The study aimed to investigate the Human Papilloma Virus (HPV) type
11, 16, and 18 in patients with oral lesions.
Sixty blocks were examined using immunohistological techniques, their ages
ranging between11-80 years with a mean age of 46 years. 50 Out of 60 patients
with oral squamous cell carcinomas (OSCCs) and the remaining ten had benign
oral lesions, included as internal control. From the 50 patients with OSCCs, 10
(20%) showed positive immunohistochemical results for HPV type (16, and18) of
which 50% were detected among males and 50% were demonstrated among
females. The ten positive findings were Immunophenotyped as follows: five were
positive with HPV type 16, four with type 18 and one was positive for 16 and18.
None of them were positive for HPV type 11. All patients with benign oral lesions
were negative for HPV immunohistochemistry.
.
In regard to the relationship between types of HPV and the grade of OSCCs,
well differentiated SCCs with positive HPV were six and 27 were negative.
Moderate SCCs with positive HPV were three and 10 were negative. Patients
with poorly differentiated
SCCs were only two, and one of them was positive.
This relation decrease with increase grade of OSCCs was found to be
statistically insignificant (P. <0.05).
The distribution of HPV according to patient’s residence was: one from
Khartoum, one from the south and eight from the northern part of the Sudan. The
study concludes that HPV associated with some cases of OSCCs.
The study recommended screening more patients who suffer from OSCC
using more advanced Immunohistochemical, molecular techniques to confirm the
role of the HPV in developing of OSCC in the Sudan.
