Evaluation of Vitamin D and Magnesium Levels in Breast Cancer Patients Khartoum State 2013

Abstract

A descriptive cross-sectional study was conducted in the Radiation & Isotopes Centre Khartoum (RICK), Khartoum stat; ninety subjects were enrolled in this study, sixty breast cancer patients and thirty apparently healthy females as control group. Vitamin D was estimated using Euroimmune 25-OH vitamin D competitive ELISA kit, while magnesium was estimated using xylidyl blue method, questioner and results data obtained then analyzed using SPSS. The results showed, majority of breast cancer patients at age 41-60 which compose 45%. Ourstudy found decrease in mean of serum vitamin D level among patients compared with control group resulting ( P- in value=0.000),also decrease of vitamin D level showed in postmenopause compared with premenaupose breast cancer patients (P- value0.046).Significant increase was showed in mean serum magnesium concentration of patients in comparison with control group ( P-value 0.000). There are no significant differences in the mean of serum vitamin D and magnesium level in breast cancer classified according to their parity (number of children), body mass index, and duration of disease, and also our study results showed week negative correlation between vitamin D and magnesium. The present study conclude that,there was decrease in vitamin D level among Sudanese women with breast cancer especially in menopause one andincrease in serum magnesium concentration. Trail vitamin D study was recommended to evaluate the dose of vitamin D which must be supplemented to breast cancer patient also to study the vitamin D and magnesium in correlation with breast cancer stage and metastasis.