Abstract:
This is a retrospective study conducted in Radiation Isotope centre-Khartoum
during December 2009 - April 2010. The study aimed to investigate Human
Papilloma Virus (HPV) in oral tumor patients were referred to Radiation Isotope
centre-Khartoum. HPV was investigate among 55 patients aged between 31-71
years (40 were oral squamous cell carcinoma (OSCC) and 15 were benign
lesion). The DNA was extected from tissue sample then polymerase Chain
Reaction (PCR) applied to investigate the HPV. In this study, among 40 patients
suffering from OSCC, HPV was identified in 6 patients (10% of patients were
males and 5% were females). Among HPV positive patients, 2 (5%) were
diagnosed as HPV type (16), and 4 (10%) were diagnosed HPV type (18).
However, patients with benign lesion were HPV negative. Distribution of OSCC
patients was recorded according to the patient’s residency as follow; 4 patients
with OSCC from Khartoum, 1 from the centre of Sudan, 1 from the east, 10 were
from west, 6 were from the south, and 18 were from the northern Sudan. In
contrast, patients with benign oral lesions, 4 patients were from Khartoum, 1 from
the centre, 1 from the west, 3 were from the south, and 6 were from north of
Sudan. The OSS patients were diagnosed according to the pathology as fallow;
16 males and 4 females were investigated with well differentiated squamous cell
carcinoma, 9 males and 4 females were with moderate differentiated squamous
cell carcinoma, and 3 males and 4 females with poor differentiated squamous
cell carcinoma. However, 13 males and 2 females were investigated benign oral
lesion. Eventually, the existing scientific data continue to suggest that infection of
HPV plays a critical role in the development of OSCC, perhaps in conjunction
with other risk factors. The study recommended screening more patients who
suffer from OSCC using more advanced molecular techniques to confirm the role
of the HPV in developing of OSCC in Sudan.
