Abstract:
This is a hospital based longitudinal retrospective descriptive study
aimed to evaluate the expression of cytokeratin 20(CK20) in colorectal
carcinoma patients using immunohistochemistry. The study was
conducted in Khartoum state during the period from May to July 2013.
Thirty paraffin block samples were collected from patients previously
diagnosed as colorectal carcinoma in National public health laboratory
using simple random collection method. The paraffin blocks were cut by
rotary microtome, and then stained by immunohistochemical method for
detection of CK20.
The age of study population ranged between 27 and 90 years with
mean age of 54. The study revealed that the most patients were older than
50 years representing 17(56.7%) and the remaining 13(43.3%) were
younger than 50 years.
Out of thirty patients the study showed that the majority of patients
were males representing 21(70%) and the remaining 9 (30%) were
females.
CK20 among study population showed strong expression in 23(76.7%)
patients, and weak expression in 7 (23.3%) patients.
The grade of cancer of study population revealed that 16 (53.3%) were
well differentiated tumor.
The study concludes that the CK20 expression is positive in all
colorectal carcinoma tissue and the majority of expression is strong. With
no association with the grade of cancer.
