Expression of Estrogen and Progesterone Receptors in Breast Cancer Among Sudanese Females in Khartoum state 2008-2009

Abstract

This is a descriptive hospital base study aimed to determine the expression of estrogen and progesterone receptors in breast cancer females in Khartoum state. The study was carried out in Khartoum state during the period between Jan 2008 Jan 2009. Fifty archived specimens of embedded paraffin wax block were collected from histopathology lab of Ribat hospital and directorate of labrotaries and the essential data was collected from patient form. The disease was distributed in tree group of age women less than 30 Years were (4%) ,women between 30-50years were (43%) and women over 50 years were (53%), Ductal carcinoma is the most distributed type of breast cancer among the study group (74%). After applying imunohistochemstry technique using avidin biotin method the results showed that out of (37) women having ductal carcinoma with ER positive are 10(20%) whereas carcinoma with ER negative is 27(54%). While out of (13) with non- ductal carcinoma with the expression of ER positive are 12 (24%) and those with non- ductal carcinoma and ER negative are 1 (2%).with significant correlation between types of breast cancer and expression of ER receptors P. value <o.o1. Females having ductal carcinoma and positive expression of PR receptor were 10 (20%), ductal carcinoma and negative expression of PR receptor were 27(54%), non-ductal carcinoma and positive expression of PR receptor were 3(6%) and non-ductal carcinomas negative expression were PR receptor were 10(20%) With significant correlation between type of breast cancer and expression of PR receptor, P. value <0.01. The incidence of ER/PR subtypes among the study group showed (ER+/PR+)were 24% those having( ER+/PR- )were 12%. Those having (ER-/PR+) were 4%,those having (ER-/PR-)were high incidence shows 60%. The study showed that there is no significant correlation between age and type of cancer also between age and expression of ER and PR receptors. The study recommended more effort for breast cancer were needed, also large sample size to determine the expression of ER and PR receptors among breast cancer. Appling the immunohistochemestry investigation for (ER-/PR-) negative receptors as routine test to help diagnosis , treatment by hormonal therapy and prognosis.