Abstract:
This study was conducted at Khartoum Teaching Hospital (Renal dialysis
Unit) in the period between 12/2009-2/2010 in order to assess the
coagulation mechanism into two clinical groups, acute and chronic renal
failure patients. individual recruited for this study include 40 patients (8
acute renal failure and 32 chronic renal failure , of them were 28 males
and 12 females) of a mean age of 40.6 years and 14 healthy individuals
considered as control. Among those patients, there were 15 hypertensive,
2 diabetics, and 4 Hepatitis C virus. Blood samples were collected from
both patients and controls and used for laboratory investigations of
activated partial thromboplastin time (aPTT) , prothrombin time (PT) ,
and platelets count using routine methods. The results of this study
showed prolongation of PT and aPTT and a decrease in platelet count
compared to the control ,the difference was statistically significant in
platelets counts of chronic cases (p<0.001). In renal failure that
associated with other diseases, the results showed a prolongation in the
PT and the aPTT, the prolongation was significant only in patients with
hepatitis C (p<0.007). The platelet count was significantly decreased in
all cases associated with renal failure (p< 0.05). The present work
concluded the renal failure patients are at high risk of bleeding due to
thrombocytopenia ,platelets disfunction . And venous thromboembolism
due to loss of antithrombinIII ,factor IX ,XII ,and prekalkrein , and
decreased of protein C activity.
