Estimation of Fibrinogen level among Sudanese patients Smokers in Khartoum Teaching Hospital

Abstract

This is a cross-sectional descriptive and analytical study, conducted at Khartoum teaching hospital during the period from March 2010/ September 2010. The aim of this study was to estimate the fibrinogen level in Sudanese smokers who attended in Khartoum teaching hospital. Sixty Sudanese healthy smokers were informed about the study and their agreement for participation was obtained. The study population was divided in to three groups according to the duration of smoking and number of cigarettes smoked per day as follows: The first group was smoking for less than 10 years, the mean of fibrinogen level was 3.33g/L , while the second group were smoking for 10 to 20 years, the mean of fibrinogen level was 5.39g/l. And the third group was smoking for more than 20 years, the mean of fibrinogen level was 7.14g/l. According to the number of cigarettes smoked per day the population was also divided into three groups, the mean of fibrinogen level was 3.41g/l in the first group who smoked less than 10 cigarette /day, 5.7g/l in the second group who smoked from 10 to 20 cigarette /day, and 6.97g/l in the third group who smoked more than 20 cigarette /day. The results obtained indicated that the fibrinogen level was in the normal range in the first group according to intensity and duration of smoking. But in comparison with control group, fibrinogen level was statistically higher. While the fibrinogen level was much raised in the other groups and the rise is statistically significant in comparison with control group, p value=0.000. Finally, In conclusion the results obtained in the current investigation proved that smoking increased the level of fibrinogen and the increase in level is directly related to the duration of smoking and number of cigarettes smoked/day.