Abstract:
Background. Cardiac troponin T (cTnT) is a cardiac regulatory protein that
control the calcium mediated interaction between actin and myosin, TnT is a
component of the contractile apparatus of the striated musculature. As a result
of its high tissue-specificity, cardiac troponin T (cTnT) is a cardio-specific,
highly sensitive marker for myocardial damage.
Objective. This study aimed to measure and evaluate the usefulness of
Troponin T and lipid profile in hypertensive patients who had developed chest
pain due to cardiac event .
Subjects and Methods. Cardiac troponin T(cTnT) and lipid profile were
measured with a quantitative laboratory methods for one hundred hypertensive
patients and 100 apparently healthy subjects as a control group. Cardiac
troponin T was measured by Elecsys 2010 and lipid profile were measured by
enzymatic method.
Results.
The results of this study revealed a significant elevation of troponin T and
HDL-C levels in hypertensive patients and also showed a significant
correlation between troponin t and total Cholesterol ( P value= 0.001, R =
0.341) , there was a significant increase in the levels of troponin T and HDL
cholesterol (p<0.05) in hypertensive patients as compared to those in the
healthy controls. On applying Pearson’s correlation,
in hypertensive patients there was significant correlation between Troponin T
and total TC ( P- value= 0.001, R = 0.341) , Troponin T and Triglyceride ( P-
value= 0.029,R = 0.218) , Troponin T and LDL (P- value =0.002 ,R = 0.309) ,
duration of disease and Troponin T (P-value 0.038 ,R = 0.208) , duration of
disease and TC (P-value=0.041, R=0.205) , duration of disease and LDL (P-
value= 0.017 , R = 0.238), systolic blood pressure and troponin T (P-value=
0.011 ,R = 0.254), systolic blood pressure and LDL (P-value=0.032, R=0.215),
diastolic blood pressure and TC (p-value=0.010, R=0.257) and diastolic blood
pressure and LDL (P-value=0.010, R=0.250).
A significant correlations between Trooponin T and HDL, body weight and
Troponin T, body weight and TC, body weight and TG, body weight and
HDL, body weight and LDL, duration of disease and TG, duration of disease
and HDL, systolic blood pressure and TC, systolic blood pressure and TG,
systolic blood pressure and HDL, diastolic blood pressure and troponin T,
diastolic blood pressure and TG and diastolic blood pressure and HDL, P-
value >0.05 for all, which were statistically not significant.
Conclusion. This study confirms that the cardiac troponin T can be used as a
predictor for the early detection of cardiac event along with the lipid profile
markers in hypertensive patients .
