Abstract:
A case-control study conducted during the period
from January 2011 to December 2012, compared the
plasma levels of alanine transaminase, aspartate
transaminase, alkaline phosphatase, bilirubin, total
protein, albumin and HbA1c of 200 Sudanese patients
with long standing Type2 diabetes mellitus ( as a test
group) and 100 apparently healthy volunteers (as a
control group).Participants in this study were from
Jaber Abu Elez diabetic center in Khartoum state,
Sudan. Age and sex of the test group were matched
with the control group. The plasma levels of ALT, AST,
ALP, bilirubin, total protein, albumin and HbA1c were
measured using a semi automated methods. The
means of the plasma levels of ALT, AST, ALP, bilirubin
and HbA1c% of the diabetic group were significantly
raised when compared to the control group. The
means of the plasma levels of total protein and
albumin of the diabetic group were significantly
reduced when compared to the control group. In the
diabetic group the plasma levels of ALT, AST, ALP and
bilirubin show positive correlations with duration of
diabetes,HbA1c and BMI, whereas the plasma level of
total protein and albumin shows negative correlation
with the duration of diabetes , ,HbA 1c and BMI. From
the results of this study, it is concluded that: in
Sudanese patients, type2 diabetes mellitus is
associated with high plasma levels of ALT, AST, ALP
and bilirubin and low levels of total protein and
albumin. In addition, there are positive correlation
between the plasma levels of ALT, AST, ALP and
bilirubin with the duration of diabetes, HbA 1c and BMI.
And negative correlation between plasma levels of
total protein and albumin with duration of diabetes,
HbA1c and BMI.
