Abstract:
This is hospital
bass cross sectional analytical study in Sudan cardiac center
(Khartoum State) during the period March to July 2011 .In Open heart Surgery
Patients to evaluate routine coagulation profile and platelets count. Open heart
surgery patients were selected for this study 50 blood sample were collected
before surgery and 50 sample were collected after surgery to evaluate coagulation
profile by manual methods and platelets count by sysmex automated method. The
gender distribution showed that male 33 (66%) and female 17 (34%)
Prothrombin time pre surgery was
seconds with significant
were
15.37 seconds, and post surgery was 21.84
difference ( P. value .000 ) . Activated partial
thromboplastin time pre surgery was 35.08 seconds and post surgery was 42.74
seconds with significant difference ( P. value 0.001) . Platelets count pre surgery
was 231.92 , and post surgery was 216.86 with significant difference ( P. value
0.001). All the coagulation profile showed
prolongation , platelets count
decreased from the count pre surgery .The reduced amount of coagulation factors
after surgery due to exposure of the patients blood to cardiopulmonary bypass
circuitry diminishes the hypercoagulable state and proceeds into an imbalanced
hypocoagulable phase as conclusion open heart surgery were effected the
haemostatic mechanism in both male and female the ( PT,INR, APTT ) showed
. significant prolongation and platelets count showed significant decrease
