Assessment of Glomerular Filtration Rate in Some Sudanese Diabetic Patients

Abstract

The objective of this study is to determine the level of creatinine clearance among Sudanese diabetic patients and compare it with a healthy control group. Diabetic nephropathy is a progressive kidney disease caused by angiopathy of capillaries in the kidney glomeruli. It is due to longstanding diabetes mellitus. Cross –sectional descriptive study was conducted in Shendi town during the year 2011. The study included 150 subjects, 100 of them were diagnosed as diabetics and 50 of them were apparently healthy individuals as control group. Their ages were ranged from 17 to 90 years, 37% of them were males and 63% of them were females. Venous blood sample were obtained from diabetic patients and control group for serum creatinine by Jaffe kinetic method, spectrophotometer is used, then calculate the creatinine clearance by The Cockcroft-Gault formula by using serum creatinine, weight and age. The results had shown that the mean of creatinine clearance in diabetic patient was lowered (79.1 ml/minute) when it compared to control group (102.9 ml/minute) with significance correlation(p.value =0,000). The study also showed the creatinine clearance was lower in type I diabetic patients (67.4 ml/minute) when compared to type II diabetic patients (83.4 ml/minute) with significance correlation(p.value =0,000). The study also showed the mean of creatinine clearance in diabetic patient with age less than 40 year was 75.8 ml/minute, and in age between 40 – 49 year were 80.5 ml/minute, and age of 50 to 59 was 79.4 ml/minute and in age more than 60 year was 62.8 ml/minute. The study also showed the mean of creatinine clearance in male diabetic patient was 76.9 ml/minute and in female patient was 80.3 ml/minute with insignificance correlation (p.value =0,66). The study also showed the mean of creatinine clearance in diabetic patient that has regular exercise was 83.7 ml/minute and in patient irregular exercise was 73.8 ml/minute with significance correlation (p.value =0,05). The study also showed the mean of creatinine clearance in diabetic patient with weight less than 50 Kg was 60.5 ml/minute, and in weight between 50 – 59 Kg was 61.3 ml/minute, and in weight of 60 to 69 Kg ‫‪was 80 ml/minute, and in weight of 70 to 79 Kg was 81.1 ml/minute and‬‬ ‫.‪in weight more 79 Kg was 98.9 ml/minute‬‬ ‫‪The study also showed the mean of creatinine clearance in diabetic‬‬ ‫‪patient with duration of disease 1- 5 year was 86 ml/minute, and in‬‬ ‫,‪diabetic patient with duration of disease 6- 10 year was 75.1 ml/minute‬‬ ‫9.47 ‪and diabetic patient with duration of disease more than 10 year was‬‬ ‫.‪ml/minute‬‬ ‫‪The study Show there is 5% (n=5) of the patient have proteinuria‬‬