Abstract:
This study was performed in Khartoum state during the period from January to May 2011.
The aim of the study is to compare the sensitivity of C – reactive protein and GFR as a marker
of Diabetic Nephropathy in Sudanese with type 2 diabetes mellitus.
Seventy five blood samples were collected from diabetic Sudanese patient with type 2 diabetes
mellitus, and seventy five healthy volunteers control group for the comparison, GFR was
calculated by using the equation of Cockcroft-Gault and CRP level was estimated
turbidmetrically with automation technique (Mindary BS 300).
The study observed significant increase in the C-reactive protein level in the test group of
type 2 diabetes mellitus when compared with control group (4.56±o.89 mg/L verses 1.57±0.76
mg/L) respectively (P = 0.000). Where as GFR was significantly decreased in the study group
when compared with control group (94.04±12.3 ml/min, verses 115.12 ±13.7 ml/min)
respectively, (P = 0.000). Significant maximum level of C-reactive protein in the test group with
type 2 diabetes mellitus was recorded in the duration of the disease from 1 year to 5 years
(5.2±1.0mg/L, versus1.7±0.65mg/ L) (p = 0.000), In contrast, no significant decrease in mean
GFR in the test group with type 2 diabetes mellitus compared with their control in the same
duration of the disease from 1 year to 5 years (99.74 ±11.38ml/min, versus115±13.2ml/min) (p
=0.03). The study recorded insignificant correlation between serum C-reactive protein levels
with both the duration of type 2 diabetes mellitus and the patient's age (P =0.647 )(P=0.846)
In conclusion: CRP is higher in test group of type 2diabetes mellitus than in healthy
individuals, and reached the peak maximum in the first five years from the onset of
type2diabetes mellitus, In contrast, GFR reached the minimum reduction after sixteen years from
the onset of the type 2 diabetes mellitus.
