Abstract:
This is analytical, descriptive and cross-sectional
study conducted to determine the frequency of the
sickle cell disease and sickle cell trait in Sudanese
patients referred to Algeneina hospital in West
Darfur state in the period between January 2011 to
June 2011.
One hundred fifty (150) patients were informed
their parents about consent for participation was
obtained. A venous blood of 2-5ml was collected in
ethylene-diamine-tetra-acetic
acid
(EDTA)
containers and investigated for sickle cell disease
and sickle cell trait, a complete blood count (CBC)
[semi automated hematological analyzer (Sysmex
kx21N)]was used, sickling test and hemoglobin
electrophoresis were carried out, and statistical
package
for
social
sciences
(SPSS)
computer
program version 10 was used for data processing.
The mean age of the sickle cell disease patients was
6 years.
The result showed that percentage of sickle cell
disease and sickle cell trait were (38.7%) and (24%)
respectively.
Total erythrocyte count, hemoglobin level and
packed cell volume the sickle cell disease were
(3.19x103/μl) ± SD, (8.1g/dl) ±SD and (26.1%)
respectively.
There were no significant differences in sickle cell
disease and normal individual in mean cell volume
(84.1fL)± SD, mean cell
hemoglobin (26.7pg)±SD
and mean cell hemoglobin concentration (31.5g/dl )
± SD. (P.Value > 0.05).
The total leukocyte count (20.2x103/μl) ±SD and
platelets
count
(330.6x103/μl)
±SD
were
significantly elevated in sickle cell disease when
compared
with
normal
individuals
(P.Value
=
0.000).
In conclusion, sickle cell anemia is highly frequent
in the studied area which is most likely related to
the consanguineous marriages.
