Assessment of HbA1c in Healthy Pregnant Sudanese Women

Abstract

A descriptive, cross sectional study was conducted in Sudan, Khartoum state in Yastabsheron obstetric hospital during the period from February to June 2011. Analytical and statistical methods were applied to estimate the concentration of HbA1c in apparently healthy pregnant Sudanese women as well as in apparently healthy non pregnant Sudanese women to assess the difference in the results. . Blood samples were taken from a total of 90 apparently healthy pregnant women (test group) with age between 17 to 45 years, and 30 apparently healthy non pregnant women (control group) with ages between 21 to 39years.Samples were analyzed for HbA1c by using affinity chromatography method, and results were recorded in addition to their age, body mass index and the number of pregnancies, then results were statistically analyzed. Result showed that, the mean concentration of the HbA1c in cases group was (4.407±1.044) % in first trimester, (4.797±0.621) % in second trimester and (4.823±0.616) % in third trimester, and (5.660 ±0.461%) in control group with a P value of 0.00, indicating the highly significant difference between the two groups. The study also showed that the mean concentration of HbA1c of the first trimester is lower than that of the second and third trimesters, but there was no significant difference between the mean concentration of the second and third trimester. On the other hand, the study showed that there was a significant positive correlation between HbA1c concentration with both the body mass index (p.value:0.011) and the age of pregnant women (p.value:0.028), but an ‫‪insignificant positive correlation with the number of pregnancies‬‬ (p.value‬‬:0.221).